Affordable Access

Publisher Website

Effect of antiorthostatic hypokinetic/hypodynamia on urinary endothelin-1 andN-acetyl-β-d-glucosaminidase excretion in rats

Authors
Journal
Clinica Chimica Acta
0009-8981
Publisher
Elsevier
Publication Date
Volume
260
Issue
1
Identifiers
DOI: 10.1016/s0009-8981(96)06506-0
Keywords
  • Antiorthostasis
  • Endothelin-1 (Et-1)
  • N-Acetyl-β-D-Glucosaminidase (Nag)
  • Kidney
  • Urine
  • Rat

Abstract

Abstract In an experimental model with rats in head-down suspension, plasma levels and urinary excretion of endothelin-1 (ET-1) and urinary excretion of N-acetyl-β- d-glucosaminidase (EC 3.2.1.30; NAG) were determined. Significant variations in time in the effective plasma ET-1 levels in the superior and inferior cava vessel blood of animals maintained for 6 days in hypogravity with respect to controls were observed. We not only found a transient increase in urinary NAG activity but also that the levels of U-ET-1 increased during head-down suspension. The simultaneous evaluation at urinary level of these two parameters could be an indication that there are different sites of renal parenchymal involvement or injury during antiorthostatic hypokinesis.

There are no comments yet on this publication. Be the first to share your thoughts.