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Cyclic 3′,5′-nucleotide phosphodiesterase:Demonstration of an activator

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
38
Issue
3
Identifiers
DOI: 10.1016/0006-291x(70)90747-3
Disciplines
  • Biology

Abstract

Abstract The activity of a mixture of a purified and a crude cyclic 3′,5′-nucleotide phosphodiesterase was greater than the summed activities of the individual preparations. The crude enzyme contained an activator, which was removed from the purified enzyme during purification. The activator, isolated free of phosphodiesterase activity, effectively reconstituted the activity of the purified enzyme. The relative inactivity of purified phosphodiesterase was due to removal of the activator from the enzyme.

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