Affordable Access

Publisher Website

Distribution tissulaire, infracellulaire et fixation du [14C]MCA ou de ses derives sur les constituants cellulaires ches les souris meres, les foetus et les neonates

Authors
Journal
Chemico-Biological Interactions
0009-2797
Publisher
Elsevier
Publication Date
Volume
7
Issue
2
Identifiers
DOI: 10.1016/0009-2797(73)90017-3
Disciplines
  • Biology

Abstract

Abstract Distribution of [ 14C]MCA and its derivatives in mouse tissues The distribution of radioactivity due to 3-methylcholanthrene (MCA) and/or its metabolites was evaluated in different organs of mothers, foetuses and newborns at 6 and 60–66 h following a single intragastric administration of 1 mg of [ 14C]MCA to pregnant CF-1 mice. The extent of bound [ 14C]MCA nd/or its metabolites to nuclear and cytoplasmic proteins was evaluated in organs which were proven to be either susceptible (lung) or non-susceptible (kidney) to the carcinogenic effect of MCA. The present data indicate a slightly higher level of free and bound MCA in the subcellular fractions of the lung than in the kidney and concurrently a higher level of covalently bound MCA to the nuclear DNA in the lungs than in the kidney.

There are no comments yet on this publication. Be the first to share your thoughts.