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Evidence for projections from the rostral medullary raphe onto medullary catecholamine neurons in the rat

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
108
Identifiers
DOI: 10.1016/0304-3940(90)90700-j
Keywords
  • Medullary Raphe Nuclei
  • Medullary Catecholamine Neuron
  • Phaseolus Vulgarisleucoagglutinin
  • Immunocytochemistry

Abstract

Abstract Following the iontophoretic deposition of Phaseolus vulgaris leucoagglutinin (PHA-L) into the rostral medullary raphe, which included portions of the caudal nucleus raphe magnus, rostral nucleus raphe pallidus, rostral nucleus raphe obscurus and rostral nucleus reticularius paragigantocellularis, two-color immunoperoxidase staining was employed to demonstrate continguity between PHA-L-immunoreactive (PHA-LI) varicose fibers and boutons and medullary catecholamine (CA) cells. Raphe projections were contiguous with phenylethanolamine N-methyltransferase-immunoreactive (PNMTI) neurons in the C1, C2 and C3 cell groups and with tyrosine hydroxylase-immunoreactive (THI) neurons in the A1 and A2 cell groups. Contiguity between PHA-LI processes and medullary CA cells was observed most frequently in the C1 cell group. Preliminary findings of this study have been presented previously.

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