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The Chimeric Receptor between Interleukin-2 Receptor β Chain and Interleukin-4 Receptor Transduces Interleukin-2 Signal

Authors
Publisher
Elsevier Inc.
Publication Date
Volume
190
Issue
3
Identifiers
DOI: 10.1006/bbrc.1993.1147

Abstract

Abstract Transfectants expressing the chimeric receptor which has human interleukin-4 receptor (hIL-4R) in the extracellular domain and human interleukin-2 receptor β chain (hIL-2Rβ) in the cytoplasmic domain showed continuous growth in response to human interleukin-4 (hIL-4), whereas transfectants expressing hIL-4R responded only transiently to hIL-4. The pattern of tyrosine phosphorylation induced by hIL-4 in transfectants expressing the chimeric receptor was very similar to that in transfectants expressing hIL-2Rβ, but different from that in transfectants expressing hIL-4R, indicating that the chimeric receptor transduces the interleukin-2 like growth signal by hIL-4.

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