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Antiproliferative Effects of 9-P-D-Arabinofuranosyladenine in a Mammalian Cell Line Devoid of Adenosine Deaminase Activity

Authors
Journal
Journal of Dental Research
0022-0345
Publisher
SAGE Publications
Publication Date

Abstract

The antiviral drug arabinosyladenine inhibited cellular growth and DNA synthesis in an adenosine deaminase-negative cell line (B-mix K-44/6). Use of adenosine deaminase-containing calf serum in the culture medium reversed the drug-induced inhibition and resulted in a recovery of both mitosis and the rate of DNA synthesis.

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