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Enzyme assisted syntheses of chiral building blocks for isosters of diglycerides, phospholipids and PAF

Authors
Journal
Tetrahedron Asymmetry
0957-4166
Publisher
Elsevier
Publication Date
Volume
15
Issue
18
Identifiers
DOI: 10.1016/j.tetasy.2004.07.047
Disciplines
  • Biology

Abstract

Abstract Lipase catalyzed desymmetrizations of suitably substituted, achiral 1,3-diols lead to the corresponding chiral building blocks of high enantiomeric purities, starting materials for the synthesis of isosteric carba-analogues of 1,2- sn-diglycerides and phospholipids with interesting biological activities. Lipase catalyzed resolutions of the corresponding ether derivatives lead to the corresponding building blocks for carba-analogues of PAF.

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