Affordable Access

Publisher Website

BL-1023 improves behavior and neuronal survival in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-intoxicated mice

Authors
Journal
Neuroscience
0306-4522
Publisher
Elsevier
Publication Date
Volume
180
Identifiers
DOI: 10.1016/j.neuroscience.2011.02.015
Keywords
  • Parkinson'S Disease
  • Neuroprotection
  • Dopamine
  • Motor Function
  • Behavior
  • 1-Methyl-4-Phenyl-1
  • 2
  • 3
  • 6-Tetrahydropyridine
Disciplines
  • Chemistry
  • Medicine

Abstract

Abstract The therapeutic potential of BL-1023, a chemical combination of l-3,4-dihydroxyphenylalanine ( l-DOPA) and gamma-aminobutyric acid (GABA), was investigated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxicated mice. Such animals exhibit nigrostriatal degeneration, characteristic of human Parkinson's disease. Drug was administered during and after the development of MPTP-induced nigrostriatal lesions followed by measures of motor function and behavior, surviving nigrostriatal dopaminergic neurons and termini, and striatal dopamine levels. When administered after lesion development, BL-1023 improved motor function of MPTP-mice as measured by rotarod, total floor and vertical plane movements, and stereotypic movements in open field activity tests compared to MPTP-mice without treatment. This also paralleled modest nigral dopaminergic neuronal protection. Such significant improvements in motor function, behaviors, and dopaminergic neuronal numbers were not seen when BL-1023 was administered during MPTP-induced lesion development. The data demonstrate select abilities of BL-1023 to increase dopaminergic neuronal survival and improve motor function in MPTP-mice.

There are no comments yet on this publication. Be the first to share your thoughts.