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Ceruloplasmin gene variations and substantia nigra hyperechogenicity in Parkinson disease.

Authors
Type
Published Article
Journal
Neurology
1526-632X
Publisher
Ovid Technologies (Wolters Kluwer) - American Academy of Neurology
Publication Date
Volume
63
Issue
10
Pages
1912–1917
Identifiers
PMID: 15557511
Source
Medline

Abstract

Detection of sequence variations in a single Parkinson disease (PD) patient or associated with the ultrasound marker for increased substantia nigra iron levels and the presence of ceruloplasmin (Cp) immunoreactivity in Lewy bodies underline a suspected role for Cp in the pathogenesis of PD. Further functional analyses are warranted to investigate whether these variations are causally linked to the complex pathogenesis of PD in a subset of cases.

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