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Ceruloplasmin gene variations and substantia nigra hyperechogenicity in Parkinson disease.

Authors
  • Hochstrasser, H
  • Bauer, P
  • Walter, U
  • Behnke, S
  • Spiegel, J
  • Csoti, I
  • Zeiler, B
  • Bornemann, A
  • Pahnke, J
  • Becker, G
  • Riess, O
  • Berg, D
Type
Published Article
Journal
Neurology
Publisher
Ovid Technologies (Wolters Kluwer) - American Academy of Neurology
Publication Date
Nov 23, 2004
Volume
63
Issue
10
Pages
1912–1917
Identifiers
PMID: 15557511
Source
Medline
License
Unknown

Abstract

Detection of sequence variations in a single Parkinson disease (PD) patient or associated with the ultrasound marker for increased substantia nigra iron levels and the presence of ceruloplasmin (Cp) immunoreactivity in Lewy bodies underline a suspected role for Cp in the pathogenesis of PD. Further functional analyses are warranted to investigate whether these variations are causally linked to the complex pathogenesis of PD in a subset of cases.

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