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Cerebrovascular reactivity and deep white matter hyperintensities in migraine: A prospective CO2 targeting study.

Authors
  • Lee, Mi Ji1, 2
  • Park, Bo-Yong3
  • Cho, Soohyun4
  • Kim, Seonwoo5
  • Park, Hyunjin6, 7
  • Kim, Sung Tae8
  • Chung, Chin-Sang9
  • 1 Department of Neurology, Seoul National University Hospital, Seoul, South Korea. , (North Korea)
  • 2 Seoul National University College of Medicine, Seoul, South Korea. , (North Korea)
  • 3 Department of Data Science, Inha University, Incheon, South Korea. , (North Korea)
  • 4 Department of Neurology, Uijeongbu Eulji Medical Center, Eulji University School of Medicine, Uijeongbu, South Korea. , (North Korea)
  • 5 Statistics and Data Center, Samsung Medical Center, Seoul, South Korea. , (North Korea)
  • 6 Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon, South Korea. , (North Korea)
  • 7 School of Electronic and Electrical Engineering, Sungkyunkwan University, Suwon, South Korea. , (North Korea)
  • 8 Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. , (North Korea)
  • 9 Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. , (North Korea)
Type
Published Article
Journal
Journal of Cerebral Blood Flow & Metabolism
Publisher
SAGE Publications
Publication Date
Oct 01, 2022
Volume
42
Issue
10
Pages
1879–1889
Identifiers
DOI: 10.1177/0271678X221103006
PMID: 35607990
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Several studies suggested the association of migraine with deep white matter hyperintensities (WMHs). We aimed to explore the cerebrovascular reactivity (CVR), deep WMH burden, and their association in patients with migraine using a state-of-the-art methodology. A total of 31 patients with migraine without aura and 31 age/sex-matched controls underwent 3T MRI with prospective end-tidal carbon dioxide (CO2) targeting. We quantified deep WMH clusters using an automated segmentation tool and measured voxel-wise CVR by changes in blood oxygen level-dependent signal fitted to subjects' end-tidal CO2. The association of migraine and CVR with the presence of WMH in each voxel and interaction of migraine and CVR on WMH were analysed. Patients had a higher number of deep WMHs than controls (p = 0.015). Migraine and reduced CVR were associated with increased probability of having WMHs in each voxel (adjusted OR 30.78 [95% CI 1.89-500.53], p = 0.016 and adjusted OR 0.30 [0.29-0.32], p < 0.001, respectively). Migraine had an effect modification on CVR on deep WMHs (p for interaction <0.001): i.e. the association between CVR and WMH was greater in patients than in controls. We suggest that the migraine-WMH association can be explained by the effect modification on the CVR.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. This record was last updated on 05/28/2023 and may not reflect the most current and accurate biomedical/scientific data available from NLM. The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/35607990
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