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Cerebrospinal fluid catecholamine levels in Japanese encephalitis patients with movement disorders.

Authors
Type
Published Article
Journal
Neurochemical Research
0364-3190
Publisher
Springer-Verlag
Publication Date
Volume
30
Issue
9
Pages
1075–1078
Identifiers
PMID: 16292498
Source
Medline

Abstract

Norepinephrine and dopamine have important role in movement disorders but their role in movement disorders associated with Japanese encephalitis (JE) has not been evaluated. Therefore, in the present study, cerebrospinal fluid (CSF) catecholamine levels and its metabolites in JE patients with movement disorders were compared with those without JE. CSF was collected by lumbar puncture and analyzed by HPLC-ED. Norepinephrine, dopamine and homovanillic acid concentrations were significantly (P<0.005) lower in JE patients compared to control groups. Low levels of catecholamines in JE associated movement disorders compared to idiopathic Parkinson's disease and other extrapyramidal symptoms may be due to severe structural damage to thalamus, basal ganglia and brainstem in JE patients as revealed by MRI findings.

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