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The Cerebro-Renal System- Anatomical and Physiological Considerations.

Authors
  • Rajamani, Kumar1
  • 1 Professor of Neurology, Wayne State University School of Medicine, Detroit, MI. Electronic address: [email protected]
Type
Published Article
Journal
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
Publication Date
Sep 01, 2021
Volume
30
Issue
9
Pages
105541–105541
Identifiers
DOI: 10.1016/j.jstrokecerebrovasdis.2020.105541
PMID: 33339697
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The brain and kidney both uniquely are highly susceptible to vascular injury from shared vascular risk factors. However these are not sufficient to explain the complete extent of cerebrovascular disease especially small vessel disease in its myriad presentations that patients with chronic kidney disease manifest. They both require a large amount of blood supply to function optimally. Shared anatomical and physiological factors such as the presence of strain vessels, the local vascular autoregulation that control blood supply possible, results in the vulnerability of these organs to the vascular risk factors. Because it is a bidirectional system where each affects the other, it is best considered as a cerebro-renal unit. Copyright © 2020 Elsevier Inc. All rights reserved.

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