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Cerebral Ultrasound Findings in Neonatal Lupus Syndrome

Authors
  • Zuppa, A.A.
  • Gallini, F.
  • De Luca, D.
  • Luciano, R.
  • Frezza, S.
  • de Turris, P.L.
  • Tortorolo, G.
Type
Published Article
Journal
Neonatology
Publisher
S. Karger AG
Publication Date
Nov 12, 2004
Volume
86
Issue
4
Pages
230–234
Identifiers
DOI: 10.1159/000079820
PMID: 15256800
Source
Karger
Keywords
License
Green
External links

Abstract

A prospective study was performed enrolling 11 newborns with neonatal lupus syndrome (NLS) and 22 control newborns to investigate cerebral ultrasound (US) anomalies and their relationship with clinical neurological signs and laboratory findings. Cerebral US detected a significantly higher incidence in the study group of both subependymal pseudocysts (SEPC) and subependymal hemorrhage (SEH), neither of which correlated to autoantibody levels. All infants had completely normal neurological examinations both at birth and follow-up. The etiopathogenesis of central nervous system findings in NLS is discussed. US evaluation identified minimal anomalies compatible with favorable outcome: further studies are necessary to investigate the possible long-term sequelae, pathogenesis and spectrum of cerebral US findings.

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