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Cerebral microvessel endothelium is producing endothelin.

Authors
  • Yoshimoto, S1
  • Ishizaki, Y
  • Kurihara, H
  • Sasaki, T
  • Yoshizumi, M
  • Yanagisawa, M
  • Yazaki, Y
  • Masaki, T
  • Takakura, K
  • Murota, S
  • 1 Department of Neurosurgery, Faculty of Medicine, University of Tokyo, Japan.
Type
Published Article
Journal
Brain Research
Publisher
Elsevier
Publication Date
Feb 05, 1990
Volume
508
Issue
2
Pages
283–285
Identifiers
PMID: 2407312
Source
Medline
License
Unknown

Abstract

Endothelin, a potent vasoconstrictor peptide, was recently isolated from the supernatant of the cultured endothelia of the porcine aorta and is now supposed to be the most likely candidate for the endothelium-derived contractile factor (EDCF), which is responsible for the endothelium-dependent vasoconstriction by various stimuli. In this study, the production of endothelin by the endothelia of porcine cerebral microvessels was revealed by the Northern blot analysis with porcine endothelin cDNA probe and the enzyme-linked immunosorbent assay (ELISA) with anti-porcine endothelin antibody. Our results raise the possibility that the endothelia of cerebral microvessels regulate the local blood flow within the brain through the production of endothelin.

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