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Cerebral antioedematous effect of Teproside and of some vincamine derivatives.

Authors
  • Borzeix, M G
  • Cahn, J
Type
Published Article
Journal
International journal of clinical pharmacology research
Publication Date
Jan 01, 1984
Volume
4
Issue
4
Pages
259–261
Identifiers
PMID: 6500773
Source
Medline
License
Unknown

Abstract

Alkyltin compounds are known to produce in the rat a selective oedema of the CNS, especially of the white matter. Vincamine and vincamine derivatives, among which Teproside is the most potent, are able to prevent the occurrence of such an oedematous reaction whereas xanthine derivatives and papaverine fail to prevent this oedema. It is suggested that there may be a potentiation of the effect of vincamine by the xanthine part of the Teproside chemical structure.

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