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Cerebral amyloid angiopathy-related inflammation: an emerging disease.

Authors
  • Savoiardo, M
  • Erbetta, A
  • Di Francesco, J C
  • Brioschi, M
  • Silani, V
  • Falini, A
  • Storchi, G
  • Brighina, L
  • Ferrarese, C
  • Ticozzi, N
  • Messina, S
  • Girotti, F
Type
Published Article
Journal
The neuroradiology journal
Publication Date
May 15, 2011
Volume
24
Issue
2
Pages
253–257
Identifiers
PMID: 24059616
Source
Medline
License
Unknown

Abstract

Three elderly patients with, respectively: mild cognitive impairment, severe and progressive neurologic involvement, and focal neurologic deficit, were observed. MRI showed multiple areas of white matter edema, at times partially involving the cortex, in the first two patients, and a single area in the third. Treatment with steroids determined the disappearance of the lesions and clinical amelioration. The key to the diagnosis of cerebral amyloid angiopathy-related inflammation (CAA-ri) was the demonstration, with appropriate MRI sequences, of microbleeds consistent with cerebral amyloid angiopathy (CAA). This diagnosis was supported by genetic analysis of APOE with demonstration of ε4/ε4 genotype, found in about 80% of CAA patients who develop inflammatory changes. In the appropriate clinical setting, MRI demonstration of microbleeds supported by results of genetic analysis of APOE may strongly support the diagnosis of CAA-ri thus avoiding cerebral biopsy.

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