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Cerebellar medulloblastoma in adults.

Authors
  • Hughes, P G
Type
Published Article
Journal
Journal of neurosurgery
Publication Date
May 01, 1984
Volume
60
Issue
5
Pages
994–997
Identifiers
PMID: 6716169
Source
Medline
License
Unknown

Abstract

From 1960 through 1981, 15 patients with cerebellar medulloblastoma, aged 16 years or over, were referred for irradiation following surgery. All patients received craniospinal irradiation; three patients received adjuvant chemotherapy. Five-year and 10-year survival rates of 63% and 38%, respectively, were obtained. The main cause of treatment failure was tumor recurrence in the posterior fossa. All local recurrences presented late, none developing within the first 3 years. One patient suffered systemic disease. The prognosis following relapse was poor. One patient achieved a prolonged remission following further surgery and radiotherapy, but died of treatment-related complications. The majority of the survivors are free of major deficit. One patient developed paraplegia 10 years after treatment. The possible risk of late damage to the hypothalamic-pituitary axis is discussed.

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