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Centrally active 5-HT receptor agonists and antagonists.

Authors
  • Middlemiss, D N
  • Tricklebank, M D
Type
Published Article
Journal
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier
Publication Date
Jan 01, 1992
Volume
16
Issue
1
Pages
75–82
Identifiers
PMID: 1553108
Source
Medline
License
Unknown

Abstract

Eleven subtypes of central 5-HT receptor have so far been postulated, four of which have been cloned (5-HT1A, 5-HT1C, 5-HT1D and 5-HT2) and a fifth (the 5-HT3 receptor) purified. The present review discusses the agonists and antagonists which act at these subtypes with respect to their degree of selectivity and in vivo potency. Selective agonists exist for the 5-HT1A, 5-HT1B and 5-HT3 receptors and selective antagonists for the 5-HT2 and 5-HT3 receptors.

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