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A Central role for mTOR in lipid homeostasis.

Authors
  • Lamming, Dudley W1
  • Sabatini, David M
  • 1 Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA; Howard Hughes Medical Institute, MIT, Cambridge, MA 02139, USA; Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA 02142, USA; The David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA.
Type
Published Article
Journal
Cell metabolism
Publication Date
Oct 01, 2013
Volume
18
Issue
4
Pages
465–469
Identifiers
DOI: 10.1016/j.cmet.2013.08.002
PMID: 23973332
Source
Medline
Language
English
License
Unknown

Abstract

The mechanistic target of rapamycin (mTOR) signaling pathway regulates many fundamental metabolic and physiological processes, including lipid metabolism. We explore recent findings on the role of mTOR in lipid homeostasis, with an emphasis on recent findings from in vivo models regarding the role of mTORC2 in lipolysis, lipogenesis, and adipogenesis. Copyright © 2013 Elsevier Inc. All rights reserved.

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