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The central regulation of bone remodeling.

Authors
  • Karsenty, G
Type
Published Article
Journal
Trends in Endocrinology and Metabolism
Publisher
Elsevier
Publication Date
Dec 01, 2000
Volume
11
Issue
10
Pages
437–439
Identifiers
PMID: 11091123
Source
Medline
License
Unknown

Abstract

For a long time bone remodeling has been thought to be mainly an autocrine-paracrine phenomenon. Yet bone resorption mechanisms are under the control of hormones, suggesting that the same might be true for bone formation. The recent development of molecular endocrinology uncovers a common, central regulation of bone formation, body weight and reproduction mediated by leptin.

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