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Central nitrergic system regulation of neuroendocrine secretion, fluid intake and blood pressure induced by angiotensin-II

Authors
  • Reis, Wagner L1, 2, 3
  • Saad, Wilson A4
  • Camargo, Luiz A4
  • Elias, Lucila LK4
  • Antunes-Rodrigues, José1
  • 1 Paulista State University of Araraquara. UNESP Araraquara, Department of Physiology, School of Dentistry, São Paulo, Brazil , São Paulo (Brazil)
  • 2 University of Taubaté UNITAU, Basic Institute of Biosciences, Taubaté, São Paulo, Brazil , Taubaté, São Paulo (Brazil)
  • 3 UNIARA Araraquara, Department of Exact and Natural Science, SP, Brazil , (Brazil)
  • 4 University of Sao Paulo USP, Laboratory of Neuroendocrinology, Department of Physiology, School of Medicine of Ribeirão Preto, Ribeirão Preto, Sao Paulo, Brazil , Ribeirão Preto, Sao Paulo (Brazil)
Type
Published Article
Journal
Behavioral and Brain Functions
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Oct 25, 2010
Volume
6
Issue
1
Identifiers
DOI: 10.1186/1744-9081-6-64
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundNitric oxide (NO) synthesis has been described in several circumventricular and hypothalamic structures in the central nervous system that are implicated in mediating central angiotensin-II (ANG-II) actions during water deprivation and hypovolemia. Neuroendocrine and cardiovascular responses, drinking behavior, and urinary excretions were examined following central angiotensinergic stimulation in awake freely-moving rats pretreated with intracerebroventricular injections of Nω-nitro-L-arginine methyl ester (L-NAME, 40 μg), an inhibitor of NO synthase, and L-arginine (20 ug), a precursor of NO.ResultsInjections of L-NAME or ANG-II produced an increase in plasma vasopressin (VP), oxytocin (OT) and atrial natriuretic peptide (ANP) levels, an increase in water and sodium intake, mean arterial blood pressure and sodium excretion, and a reduction of urinary volume. L-NAME pretreatment enhanced the ANG-II response, while L-arginine attenuated VP and OT release, thirst, appetite for sodium, antidiuresis, and natriuresis, as well as pressor responses induced by ANG-II.Discussion and conclusionThus, the central nitrergic system participates in the angiotensinergic responses evoked by water deprivation and hypovolemia to refrain neurohypophysial secretion, hydromineral balance, and blood pressure homeostasis.

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