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Central nitrergic system regulation of neuroendocrine secretion, fluid intake and blood pressure induced by angiotensin-II

  • Reis, Wagner L1, 2, 3
  • Saad, Wilson A4
  • Camargo, Luiz A4
  • Elias, Lucila LK4
  • Antunes-Rodrigues, José1
  • 1 Paulista State University of Araraquara. UNESP Araraquara, Department of Physiology, School of Dentistry, São Paulo, Brazil , São Paulo (Brazil)
  • 2 University of Taubaté UNITAU, Basic Institute of Biosciences, Taubaté, São Paulo, Brazil , Taubaté, São Paulo (Brazil)
  • 3 UNIARA Araraquara, Department of Exact and Natural Science, SP, Brazil , (Brazil)
  • 4 University of Sao Paulo USP, Laboratory of Neuroendocrinology, Department of Physiology, School of Medicine of Ribeirão Preto, Ribeirão Preto, Sao Paulo, Brazil , Ribeirão Preto, Sao Paulo (Brazil)
Published Article
Behavioral and Brain Functions
Springer (Biomed Central Ltd.)
Publication Date
Oct 25, 2010
DOI: 10.1186/1744-9081-6-64
Springer Nature


BackgroundNitric oxide (NO) synthesis has been described in several circumventricular and hypothalamic structures in the central nervous system that are implicated in mediating central angiotensin-II (ANG-II) actions during water deprivation and hypovolemia. Neuroendocrine and cardiovascular responses, drinking behavior, and urinary excretions were examined following central angiotensinergic stimulation in awake freely-moving rats pretreated with intracerebroventricular injections of Nω-nitro-L-arginine methyl ester (L-NAME, 40 μg), an inhibitor of NO synthase, and L-arginine (20 ug), a precursor of NO.ResultsInjections of L-NAME or ANG-II produced an increase in plasma vasopressin (VP), oxytocin (OT) and atrial natriuretic peptide (ANP) levels, an increase in water and sodium intake, mean arterial blood pressure and sodium excretion, and a reduction of urinary volume. L-NAME pretreatment enhanced the ANG-II response, while L-arginine attenuated VP and OT release, thirst, appetite for sodium, antidiuresis, and natriuresis, as well as pressor responses induced by ANG-II.Discussion and conclusionThus, the central nitrergic system participates in the angiotensinergic responses evoked by water deprivation and hypovolemia to refrain neurohypophysial secretion, hydromineral balance, and blood pressure homeostasis.

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