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Central nervous system activity of a novel class of annelated 1,4-benzodiazepines, aminomethylene-2,4-dihydro-1H-imidazo[1,2-a][1,4]benzodiazepin-1-ones.

Authors
  • Ager, I R
  • Danswan, G W
  • Harrison, D R
  • Kay, D P
  • Kennewell, P D
  • Taylor, J B
Type
Published Article
Journal
Journal of medicinal chemistry
Publication Date
Aug 01, 1977
Volume
20
Issue
8
Pages
1035–1041
Identifiers
PMID: 19630
Source
Medline
License
Unknown

Abstract

The synthesis and CNS activity of a noval class of annelated 1,4-benzodiazepines, the aminomethylene-2,4-dihydro-1H-imidazo[1,2-a][1,4]benzodiazepines, are described. An investigation of the structure--activity relationships in the series derived from 8-chloro-2,4-dihydro-2-dimethylaminomethylene-6-phenyl-1H-imidazo[1,2-a][1,4]-benzodiazepin-1-one (10) led to the synthesis of a group of compounds with potent minor tranquillizer activity.

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