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Central mediation and differential blockade by cannabinergics of the discriminative stimulus effects of the cannabinoid CB1 receptor antagonist rimonabant in rats.

Authors
  • Järbe, Torbjörn U C
  • LeMay, Brian J
  • Vemuri, V Kiran
  • Vadivel, Subramanian K
  • Zvonok, Alexander
  • Makriyannis, Alexandros
Type
Published Article
Journal
Psychopharmacology
Publication Date
Aug 01, 2011
Volume
216
Issue
3
Pages
355–365
Identifiers
DOI: 10.1007/s00213-011-2226-3
PMID: 21369753
Source
Medline
License
Unknown

Abstract

A neutral CB(1)R antagonist (AM4113) produced cueing effects similar to those of rimonabant and generalization likely was centrally mediated. The functional cueing effects of rimonabant are relatively short-acting, pharmacologically selective, and differentially blocked by cannabinergics.

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