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A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells.

Authors
  • Schwab, M
  • Alitalo, K
  • Varmus, H E
  • Bishop, J M
  • George, D
Type
Published Article
Journal
Nature
Publication Date
Jan 01, 1983
Volume
303
Issue
5917
Pages
497–501
Identifiers
PMID: 6304530
Source
Medline
License
Unknown

Abstract

The cellular oncogene c-Ki-ras is amplified 30- to 60-fold in cells of the mouse adrenocortical tumour Y1. The amplified oncogene is located in double minute chromosomes and in a homogeneously staining chromosomal region, common karyotypical anomalies of tumour cells. The amounts of c-Ki-ras specific mRNA and of the protein (p21) encoded by the amplified gene are correspondingly elevated. Amplification and enhanced expression of cellular oncogenes may contribute to the genesis and/or maintenance of at least some naturally occurring tumours.

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