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Cellular and molecular predictors of chronic renal dysfunction after initial ischemia/reperfusion injury of a single kidney.

Authors
  • Azuma, H
  • Nadeau, K
  • Takada, M
  • Mackenzie, H S
  • Tilney, N L
Type
Published Article
Journal
Transplantation Journal
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Jul 27, 1997
Volume
64
Issue
2
Pages
190–197
Identifiers
PMID: 9256172
Source
Medline
License
Unknown

Abstract

These data imply that chronic injury after significant initial ischemia and reperfusion occurs when there is already a 50% renal mass reduction, but not when two kidneys remain in place. Permanent nephron loss resulting from such an insult could account for this phenomenon. Early ischemia and reperfusion, if severe enough in a single kidney, may be an important antigen-independent risk factor for later renal deterioration and failure. In the context of a renal allograft, it may contribute to chronic rejection.

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