Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection

Swantje Thiele; Stephanie Stanelle-Bertram; Sebastian Beck; Nancy Mounogou Kouassi; Martin Zickler; Martin Müller; Berfin Tuku; Patricia Resa-Infante; Debby van Riel; Malik Alawi; Thomas Günther; Franziska Rother; Stefanie Hügel; Susanne Reimering; Alice McHardy; Adam Grundhoff; Wolfram Brune; Albert Osterhaus; Michael Bader; Enno Hartmann; Gülsah Gabriel

doi:10.1016/j.celrep.2020.107549

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Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection

Authors

Thiele, Swantje¹
Stanelle-Bertram, Stephanie¹
Beck, Sebastian¹
Kouassi, Nancy Mounogou¹
Zickler, Martin¹
Müller, Martin¹
Tuku, Berfin¹
Resa-Infante, Patricia¹
van Riel, Debby^{1, 2}
Alawi, Malik^{3, 4}
Günther, Thomas⁴
Rother, Franziska^{5, 6}
Hügel, Stefanie⁵
Reimering, Susanne⁷
McHardy, Alice⁷
Grundhoff, Adam⁴
Brune, Wolfram⁸
Osterhaus, Albert⁹
Bader, Michael^{5, 6, 10}
Hartmann, Enno⁶
Gabriel, Gülsah^{1, 11}

And 1 more

¹ tal Virology, Hamburg, Germany
² Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands
³ Bioinformatics Service Facility, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
⁴ Virus Genomics, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany
⁵ Molecular Biology of Peptide Hormones, Max Delbrück Center for Molecular Medicine, Berlin, Germany
⁶ Institute for Biology, Center for Structural and Cellular Biology in Medicine, University of Lübeck, Lübeck, Germany
⁷ Computational Biology of Infection Research, Helmholtz Centre for Infection Research, Braunschweig, Germany
⁸ Virus-Host Interaction, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany
⁹ Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Hannover, Germany
¹⁰ Charité-Universitätsmedizin, Berlin, Germany
¹¹ Institute of Virology, University of Veterinary Medicine, Hannover, Germany

Type

Published Article

Journal

Cell Reports

Publisher

Elsevier

Publication Date

Apr 21, 2020

Volume

31

Issue

3

Pages

107549–107549

Identifiers

DOI: 10.1016/j.celrep.2020.107549

PMID: 32320654

PMCID: PMC7172908

Source

PubMed Central

Keywords

Disciplines

Article

License

Unknown

Abstract

Thiele et al. show that importin-α3 is one of the major nuclear transporters of NF-κB in the mammalian lung. High-level TNF-α-inducing HPAIVs inhibit importin-α3 mRNA transcription by interfering with its promoter activity. Thus, HPAIVs may evade antiviral immunity in the respiratory tract by generating a bottleneck in importin-α3 availability.

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