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Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection

Authors
  • Thiele, Swantje1
  • Stanelle-Bertram, Stephanie1
  • Beck, Sebastian1
  • Kouassi, Nancy Mounogou1
  • Zickler, Martin1
  • Müller, Martin1
  • Tuku, Berfin1
  • Resa-Infante, Patricia1
  • van Riel, Debby1, 2
  • Alawi, Malik3, 4
  • Günther, Thomas4
  • Rother, Franziska5, 6
  • Hügel, Stefanie5
  • Reimering, Susanne7
  • McHardy, Alice7
  • Grundhoff, Adam4
  • Brune, Wolfram8
  • Osterhaus, Albert9
  • Bader, Michael5, 6, 10
  • Hartmann, Enno6
  • And 1 more
  • 1 l Virology, Hamburg, Germany
  • 2 Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands
  • 3 Bioinformatics Service Facility, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
  • 4 Virus Genomics, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany
  • 5 Molecular Biology of Peptide Hormones, Max Delbrück Center for Molecular Medicine, Berlin, Germany
  • 6 Institute for Biology, Center for Structural and Cellular Biology in Medicine, University of Lübeck, Lübeck, Germany
  • 7 Computational Biology of Infection Research, Helmholtz Centre for Infection Research, Braunschweig, Germany
  • 8 Virus-Host Interaction, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany
  • 9 Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Hannover, Germany
  • 10 Charité-Universitätsmedizin, Berlin, Germany
  • 11 Institute of Virology, University of Veterinary Medicine, Hannover, Germany
Type
Published Article
Journal
Cell Reports
Publisher
Elsevier
Publication Date
Apr 21, 2020
Volume
31
Issue
3
Pages
107549–107549
Identifiers
DOI: 10.1016/j.celrep.2020.107549
PMID: 32320654
PMCID: PMC7172908
Source
PubMed Central
Keywords
License
Unknown

Abstract

Thiele et al. show that importin-α3 is one of the major nuclear transporters of NF-κB in the mammalian lung. High-level TNF-α-inducing HPAIVs inhibit importin-α3 mRNA transcription by interfering with its promoter activity. Thus, HPAIVs may evade antiviral immunity in the respiratory tract by generating a bottleneck in importin-α3 availability.

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