Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection
- Authors
- Type
- Published Article
- Journal
- Cell Reports
- Publisher
- Elsevier
- Publication Date
- Apr 21, 2020
- Volume
- 31
- Issue
- 3
- Pages
- 107549–107549
- Identifiers
- DOI: 10.1016/j.celrep.2020.107549
- PMID: 32320654
- PMCID: PMC7172908
- Source
- PubMed Central
- Keywords
- License
- Unknown
Abstract
Thiele et al. show that importin-α3 is one of the major nuclear transporters of NF-κB in the mammalian lung. High-level TNF-α-inducing HPAIVs inhibit importin-α3 mRNA transcription by interfering with its promoter activity. Thus, HPAIVs may evade antiviral immunity in the respiratory tract by generating a bottleneck in importin-α3 availability.