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Cellular Dialogues: Cell-Cell Communication through Diffusible Molecules Yields Dynamic Spatial Patterns.

Authors
  • Dang, Yiteng1
  • Grundel, Douwe A J1
  • Youk, Hyun2
  • 1 Kavli Institute of Nanoscience, Delft University of Technology, Delft 2629HZ, the Netherlands; Department of Bionanoscience, Delft University of Technology, Delft 2629HZ, the Netherlands. , (Netherlands)
  • 2 Kavli Institute of Nanoscience, Delft University of Technology, Delft 2629HZ, the Netherlands; Department of Bionanoscience, Delft University of Technology, Delft 2629HZ, the Netherlands; CIFAR, CIFAR Azrieli Global Scholars Program, Toronto, ON M5G 1M1, Canada. Electronic address: [email protected] , (Canada)
Type
Published Article
Journal
Cell systems
Publication Date
Jan 22, 2020
Volume
10
Issue
1
Identifiers
DOI: 10.1016/j.cels.2019.12.001
PMID: 31954659
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Cells form spatial patterns by coordinating their gene expressions. How a group of mesoscopic numbers (hundreds to thousands) of cells, without pre-existing morphogen gradients and spatial organization, self-organizes spatial patterns remains poorly understood. Of particular importance are dynamic spatial patterns such as spiral waves that perpetually move and transmit information. We developed an open-source software for simulating a field of cells that communicate by secreting any number of molecules. With this software and a theory, we identified all possible "cellular dialogues"-ways of communicating with two diffusing molecules-that yield diverse dynamic spatial patterns. These patterns emerge despite widely varying responses of cells to the molecules, gene-expression noise, spatial arrangements, and cell movements. A three-stage, "order-fluctuate-settle" process forms dynamic spatial patterns: cells form long-lived whirlpools of wavelets that, following erratic dynamics, settle into a dynamic spatial pattern. Our work helps in identifying gene-regulatory networks that underlie dynamic pattern formations. Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.

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