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Cellular activity of osteoblasts in the presence of hydroxyapatite: an in vitro experiment.

Authors
  • Alliot-Licht, B1
  • Gregoire, M
  • Orly, I
  • Menanteau, J
  • 1 U-225 INSERM, Faculté de Chirurgie Dentaire, Nantes, France. , (France)
Type
Published Article
Journal
Biomaterials
Publisher
Elsevier
Publication Date
Oct 01, 1991
Volume
12
Issue
8
Pages
752–756
Identifiers
PMID: 1665992
Source
Medline
License
Unknown

Abstract

The use of synthetic calcium phosphate as bone substitute calls for the knowledge of the influence on adjacent cells. Effects on monocytes, macrophages, synovial cells and fibroblasts have been largely described in vivo and in vitro but few data are available as concerns osteoblast responses. The present experiments tested the activity of MC3T3-E1, ROS 17/2.8 and mouse calvaria cells cultured in the presence of hydroxyapatite powders. The three osteoblast-like cells were shown to phagocytoze the calcium phosphate particles. As a consequence, they exhibit reduced cell growth and alkaline phosphatase activity. This response was different when compared with other cell types. The osteogenetic function of osteoblastic cells could be involved in these specific effects of hydroxyapatite.

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