Affordable Access

Cellular accumulation and retention of the technetium-99m-labelled hypoxia markers BRU59-21 and butylene amine oxime.

Authors
  • Zhang, X
  • Melo, T
  • Rauth, A M
  • Ballinger, J R
Type
Published Article
Journal
Nuclear Medicine and Biology
Publisher
Elsevier
Publication Date
Nov 01, 2001
Volume
28
Issue
8
Pages
949–957
Identifiers
PMID: 11711315
Source
Medline
License
Unknown

Abstract

BRU59-21 and 99mTc-butylene amine oxime (BnAO, HL91) are being evaluated for imaging hypoxia in tumors. Both tracers: 1) rapidly reached a plateau in aerobic Chinese hamster ovary cells in vitro but continuously accumulated in hypoxic cells; 2) ceased to accumulate when hypoxic cells were exposed to air; 3) showed approximately 40% retention upon washing the cells; 4) showed selective hypoxic accumulation only at 37 degrees C; 5) accumulation could be modulated by addition of electron-affinic compounds; and 6) exhibited higher accumulation in cells which overexpress cytochrome P450 reductase. Both BRU59-21 and 99mTc-BnAO share properties making them suitable for hypoxia imaging.

Report this publication

Statistics

Seen <100 times