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Cell surface immunoglobulin receptors in B cell development.

Authors
  • Pike, Kelly A
  • Ratcliffe, Michael J H
Type
Published Article
Journal
Seminars in immunology
Publication Date
Oct 01, 2002
Volume
14
Issue
5
Pages
351–358
Identifiers
PMID: 12220936
Source
Medline
License
Unknown

Abstract

Expression of surface immunoglobulin (sIg) related receptors has been conserved in phylogenetically distinct species as a critical checkpoint in B cell development. The sIg receptor comprises extracellular IgM heavy and light chains, with the potential for ligand binding, complexed to the Igalpha/Igbeta heterodimer that is responsible for signal transduction through sIg. Experimental systems, from both avian and murine models of B cell development, have been designed to identify the function of individual receptor components in B cell development. In this review, we assess the regulatory functions of different components of the sIg receptor complex during early development in experimental systems from evolutionarily distinct species.

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