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Cell membrane tracker based on restriction of intramolecular rotation.

Authors
Type
Published Article
Journal
ACS Applied Materials & Interfaces
1944-8252
Publisher
American Chemical Society
Publication Date
Volume
6
Issue
12
Pages
8971–8975
Identifiers
DOI: 10.1021/am5025897
PMID: 24878872
Source
Medline
License
Unknown

Abstract

The fluorescence of tetraphenylethylene (TPE), an archetypal luminogen, is induced by restriction of intramolecular rotation (RIR). TPE was grafted with palmitic acid (PA) onto a hydrophilic peptide to yield a cell membrane tracker named TR4. TR4 was incorporated into liposomes, where it showed significant RIR characteristics. When cells were incubated with TR4, cytoplasmic membranes were specifically labeled. TR4 shows excellent photostability and low cytotoxicity.

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