Cell membrane tracker based on restriction of intramolecular rotation.
- Authors
- Type
- Published Article
- Journal
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Publication Date
- Jun 25, 2014
- Volume
- 6
- Issue
- 12
- Pages
- 8971–8975
- Identifiers
- DOI: 10.1021/am5025897
- PMID: 24878872
- Source
- Medline
- License
- Unknown
Abstract
The fluorescence of tetraphenylethylene (TPE), an archetypal luminogen, is induced by restriction of intramolecular rotation (RIR). TPE was grafted with palmitic acid (PA) onto a hydrophilic peptide to yield a cell membrane tracker named TR4. TR4 was incorporated into liposomes, where it showed significant RIR characteristics. When cells were incubated with TR4, cytoplasmic membranes were specifically labeled. TR4 shows excellent photostability and low cytotoxicity.
