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Cell mediated immune response in miniature Sinclair swine bearing cutaneous melanomas.

Authors
Type
Published Article
Journal
Canadian journal of comparative medicine : Revue canadienne de médecine comparée
Publication Date
Volume
46
Issue
2
Pages
209–211
Identifiers
PMID: 7093814
Source
Medline

Abstract

Miniature Sinclair swine bearing cutaneous melanomas and nonmelanoma bearing littermate controls were tested for lymphocyte blastogenic response in a microculture assay. Lymphocytes were assayed for 3H-thymidine incorporation following stimulation with concanavalin A, phytohemagglutinin or pokeweed mitogen. Treatment with all mitogens revealed a significantly (p less than 0.05) reduced proliferative capacity in melanoma swine as compared to littermate controls. These results lend further support for the use of miniature Sinclair swine as a research model for human melanoma.

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