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[Cell death and its role in immunopathogenesis of infectious diseases].

Authors
  • Novosad, Jakub1
  • Holická, Monika
  • Novosadová, Martina
  • Krčmová, Irena
  • Malá, Eva
  • Krejsek, Jan
  • 1 Department of Clinical Immunology and Allergology, University Hospital, Hradec Králové, Czech Republic. [email protected] , (Czechia)
Type
Published Article
Journal
Klinicka mikrobiologie a infekcni lekarstvi
Publication Date
Jun 01, 2011
Volume
17
Issue
3
Pages
76–80
Identifiers
PMID: 21780024
Source
Medline
License
Unknown

Abstract

Cell death is still a matter of debate and scientific opinions have been challenged and are not uniform due to complexity of this issue. Recent research has brought some new evidence about the very subtle border between programmed cell death and necrosis. The concept of their mutual independence, broadly accepted for decades, is now significantly challenged. Lack of unified terminology led to the establishment of the Nomenclature Committee on Cell Death (NCCD) which provides recommendations for clear definition of distinct cell death programs. It also appeals for consistent application of this nomenclature in scientific literature. In this work, some keystone knowledge addressing three specific programmed cell death types - apoptosis, autophagic cell death, and pyroptosis which is recognized as a controversial cell death scenario on the border between programmed cell death and necrosis, is reviewed. These cell death scenarios are discussed in the context of pathogenesis of infectious diseases.

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