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Cell-cycle gene expression in lovastatin-induced medulloblastoma apoptosis.

Authors
Type
Published Article
Journal
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
Publication Date
Volume
30
Issue
4
Pages
349–357
Identifiers
PMID: 14672267
Source
Medline
License
Unknown

Abstract

Lovastatin-induced growth inhibition and apoptosis in medulloblastoma are not dependent on the regulation of Ras and c-myc gene expression, but may be mediated by p27KIP1 gene expression. Lovastatin-induced apoptosis in medulloblastoma is probably p53 independent, but p53 and p21WAF1 gene expression may also mediate anti-proliferative effects of lovastatin on specific medulloblastoma cell lines.

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