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Cell cycle control of DNA replication.

Authors
  • Stillman, B
Type
Published Article
Journal
Science (New York, N.Y.)
Publication Date
Dec 06, 1996
Volume
274
Issue
5293
Pages
1659–1664
Identifiers
PMID: 8939847
Source
Medline
License
Unknown

Abstract

The initiation of DNA replication in eukaryotic cells is a highly regulated process that leads to the duplication of the genetic information for the next cell generation. This requires the ordered assembly of many proteins at the origins of DNA replication to form a competent, pre-replicative chromosomal state. In addition to this competent complex, at least two cell cycle regulated protein kinase pathways are required to affect a transition to a post-replicative chromosomal state. Protein kinases required to establish mitosis prevent re-replication of the DNA. As cells exit mitosis, the cell cycle is reset, allowing the establishment of a new, competent replication state.

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