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Cell cycle control by a complex of the cyclin HCS26 (PCL1) and the kinase PHO85.

Authors
  • Espinoza, F H
  • Ogas, J
  • Herskowitz, I
  • Morgan, D O
Type
Published Article
Journal
Science (New York, N.Y.)
Publication Date
Nov 25, 1994
Volume
266
Issue
5189
Pages
1388–1391
Identifiers
PMID: 7973730
Source
Medline
License
Unknown

Abstract

The events of the eukaryotic cell cycle are governed by cyclin-dependent kinases (cdk's), whose activation requires association with cyclin regulatory subunits expressed at specific cell cycle stages. In the budding yeast Saccharomyces cerevisiae, the cell cycle is thought to be controlled by a single cdk, CDC28. Passage through the G1 phase of the cell cycle is regulated by complexes of CDC28 and G1 cyclins (CLN1, CLN2, and CLN3). A putative G1 cyclin, HCS26, has recently been identified. In a/alpha diploid cells lacking CLN1 and CLN2, HCS26 is required for passage through G1. HCS26 does not associate with CDC28, but instead associates with PHO85, a closely related protein kinase. Thus, budding yeast, like higher eukaryotes, use multiple cdk's in the regulation of cell cycle progression.

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