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Cell culture models in microfluidic systems.

Authors
Type
Published Article
Journal
Annual review of analytical chemistry (Palo Alto, Calif.)
Publication Date
Volume
1
Pages
423–449
Identifiers
DOI: 10.1146/annurev.anchem.1.031207.113042
PMID: 20636085
Source
Medline

Abstract

Microfluidic technology holds great promise for the creation of advanced cell culture models. In this review, we discuss the characterization of cell culture in microfluidic systems, describe important biochemical and physical features of the cell microenvironment, and review studies of microfluidic cell manipulation in the context of these features. Finally, we consider the integration of analytical elements, ways to achieve high throughput, and the design constraints imposed by cell biology applications.

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