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Cell-cell interactions in synovitis. Interactions between T lymphocytes and synovial cells.

Authors
  • McInnes, I B
  • Leung, B P
  • Liew, F Y
Type
Published Article
Journal
Arthritis Research
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jan 01, 2000
Volume
2
Issue
5
Pages
374–378
Identifiers
PMID: 11094451
Source
Medline
License
Unknown

Abstract

Mechanisms whereby T lymphocytes contribute to synovial inflammation in rheumatoid arthritis are poorly understood. Here we review data that indicate an important role for cell contact between synovial T cells, adjacent macrophages and fibroblast-like synoviocytes (FLS). Thus, T cells activated by cytokines, endothelial transmigration, extracellular matrix or by auto-antigens can promote cytokine, particularly TNF alpha, metalloproteinase production by macrophages and FLS through cell-membrane interactions, mediated at least through beta-integrins and membrane cytokines. Since soluble factors thus induced may in turn contribute directly to T cell activation, positive feedback loops are likely to be created. These novel pathways represent exciting potential therapeutic targets.

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