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The cell biology of neurogenesis.

Authors
Type
Published Article
Journal
Nature reviews. Molecular cell biology
Publication Date
Volume
6
Issue
10
Pages
777–788
Identifiers
PMID: 16314867
Source
Medline
License
Unknown

Abstract

During the development of the mammalian central nervous system, neural stem cells and their derivative progenitor cells generate neurons by asymmetric and symmetric divisions. The proliferation versus differentiation of these cells and the type of division are closely linked to their epithelial characteristics, notably, their apical-basal polarity and cell-cycle length. Here, we discuss how these features change during development from neuroepithelial to radial glial cells, and how this transition affects cell fate and neurogenesis.

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