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Cell-binding domain of adenovirus serotype 2 fiber.

Authors
  • Louis, N
  • Fender, P
  • Barge, A
  • Kitts, P
  • Chroboczek, J
Type
Published Article
Journal
Journal of virology
Publication Date
Jun 01, 1994
Volume
68
Issue
6
Pages
4104–4106
Identifiers
PMID: 8189552
Source
Medline
License
Unknown

Abstract

The adenovirus fiber appears as a long, thin projection terminated by a knob (head). The fiber consists of a trimeric protein whose head domain is thought to interact with cell receptors. The head part (amino acids 388 to 582) of adenovirus type 2 fiber was produced in a baculovirus expression system. The purified protein was shown to cross-link into trimers. It was very resistant to proteolytic attack and seemed to attain a high degree of compactness. The head domain efficiently inhibited attachment of adenovirus to receptors on the surface of HeLa cells, thereby confirming the hypothesis that the head domain interacts with viral receptors.

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