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[Cell-associated complement regulatory proteins and their relation to disease processes].

Authors
Type
Published Article
Journal
Rinsho byori. The Japanese journal of clinical pathology
Publication Date
Volume
39
Issue
12
Pages
1317–1324
Identifiers
PMID: 1723433
Source
Medline
License
Unknown

Abstract

C3-deposition is a key step for activation of the complement system, which involves C9-mediated immunocytolysis, immunoadherence, C3 receptor-mediated phagocytosis, NK potentiation, anaphylatoxin release, and amplification of C3 activation. Foreign material is eliminated even in the preimmune stage by these complement functions. Self cells, on the other hand, must circumvent the C3-attack, so that they express complement regulatory proteins, namely C3b/C4b receptor (CR1, CD35), decay-accelerating factor (DAF, CD55), membrane cofactor protein (MCP, CD46). We herein review the properties of these regulatory proteins and discuss the relationships between disease processes and the aberrance of these regulatory proteins.

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