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Celastrol inhibits breast cancer cell invasion via suppression of NF-ĸB-mediated matrix metalloproteinase-9 expression.

Authors
  • Kim, Yoonseo
  • Kang, Hyereen
  • Jang, Sung-Wuk
  • Ko, Jesang
Type
Published Article
Journal
Cellular Physiology and Biochemistry
Publisher
S. Karger AG
Publication Date
Jan 01, 2011
Volume
28
Issue
2
Pages
175–184
Identifiers
DOI: 10.1159/000331729
PMID: 21865725
Source
Medline
License
Unknown

Abstract

These results indicate that celastrol inhibits NF-κB-mediated MMP-9 expression, resulting in suppression of breast cancer cell invasion and migration that is induced by PMA. Celastrol is a potential agent for clinical use in preventing the invasion and metastasis of human malignant breast tumors.

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