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Ceftaroline modulates the innate immune and host defense responses of immunocompetent cells exposed to cigarette smoke.

Authors
  • Bruno, A1
  • Cipollina, C2
  • Di Vincenzo, S1
  • Siena, L1
  • Dino, P1
  • Di Gaudio, F3
  • Gjomarkaj, M1
  • Pace, E4
  • 1 Istituto di Biomedicina e Immunologia Molecolare, Consiglio Nazionale delle Ricerche, Palermo, Italy. , (Italy)
  • 2 Istituto di Biomedicina e Immunologia Molecolare, Consiglio Nazionale delle Ricerche, Palermo, Italy; Fondazione Ri.MED, Palermo, Italy. , (Italy)
  • 3 DiBiMeF (Biopatologia e Biotecnologie Mediche e Forensi), Università degli Studi di Palermo, Italy. , (Italy)
  • 4 Istituto di Biomedicina e Immunologia Molecolare, Consiglio Nazionale delle Ricerche, Palermo, Italy. Electronic address: [email protected] , (Italy)
Type
Published Article
Journal
Toxicology letters
Publication Date
Sep 05, 2017
Volume
279
Pages
9–15
Identifiers
DOI: 10.1016/j.toxlet.2017.07.878
PMID: 28720485
Source
Medline
Keywords
License
Unknown

Abstract

Ceftaroline counteracts the effect of CSE in immune cells by increasing the effectiveness of the innate immune system. This effect may also assist in reducing pathogen activity and recurrent exacerbations in COPD patients.

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