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Cefpodoxime — utility in respiratory tract infections and typhoid fever

Authors
  • Aggarwal, Anju1
  • Rath, Suman1
  • 1 University College of Medical Sciences and Guru Tegh Bahadur Hospital, Department of Pediatrics, Delhi, India , Delhi
Type
Published Article
Journal
The Indian Journal of Pediatrics
Publisher
Springer-Verlag
Publication Date
May 01, 2004
Volume
71
Issue
5
Pages
413–415
Identifiers
DOI: 10.1007/BF02725629
Source
Springer Nature
Keywords
License
Yellow

Abstract

Cefpodoxime is a oral third generation cephalosporin active against most of gram positive and gram negative bacteria except Pseudomonas, B. fragilis and Entrococcous. Clinical studies have confirmed efficacy of cefpodoxime in acute otitis media, sinusitis and tosillopharyngitis. Twice daily administration and safety profile increases compliance and decreases failure rate. It has a role as switch over therapy from intravenous ceftriaxone in serious respiratory tract infections (RTIs). In areas where common respiratory pathogens show decreased sensitivity to penicillins and macrolides cefpodoxime can be used as empirical first line therapy in respiratory tract infections. It seems to be a promising molecule in pediatric typhoid fever because of its excellent activity against Salmonella species but clinical trials are limited.

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