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Endothelial nitric oxide synthase gene polymorphisms and cardiovascular damage in hypertensive subjects: an Italian case-control study

Authors
Journal
Immunity & Ageing
1742-4933
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
5
Issue
1
Identifiers
DOI: 10.1186/1742-4933-5-4
Keywords
  • Research
Disciplines
  • Biology
  • Chemistry
  • Design
  • Medicine

Abstract

1742-4933-5-4.fm ral ss BioMed CentImmunity & Ageing Open AcceResearch Endothelial nitric oxide synthase gene polymorphisms and cardiovascular damage in hypertensive subjects: an Italian case-control study Daniela Colomba1, Giovanni Duro2, Salvatore Corrao1, Christiano Argano1, Tiziana Di Chiara1, Domenico Nuzzo2, Federica Pizzo2, Gaspare Parrinello1, Rosario Scaglione*1 and Giuseppe Licata1 Address: 1Department of Internal Medicine, University of Palermo, Italy and 2Institute of Biomedicine and Molecular Immunology CNR, Palermo, Italy Email: Daniela Colomba - [email protected]; Giovanni Duro - [email protected]; Salvatore Corrao - [email protected]; Christiano Argano - [email protected]; Tiziana Di Chiara - [email protected]; Domenico Nuzzo - [email protected]; Federica Pizzo - [email protected]; Gaspare Parrinello - [email protected]; Rosario Scaglione* - [email protected]; Giuseppe Licata - [email protected] * Corresponding author Abstract Background: Nitric oxide (NO) synthesized by endothelial nitric oxide synthase (eNOS) plays an important role in regulation of endothelial function and in the control of blood pressure. However, the results from some studies on the association between three clinically relevant eNOS gene polymorphisms (G894T, T786C and intron 4b/a) and essential hypertension are unclear. We designed a case-control study to evaluate the influence of eNOS polymorphisms on target organ damage in 127 hypertensives and 67 normotensives. Clinical evaluation, biochemical parameters, Urinary Albumin Excretion (UAE) and echocardiogram were performed to characterize target organ damage. eNOS polymorphism were recognized by PCR method. Results: The distribution of eNOS genotypes was similar in hypertensives and normotensives but 4aa was present in the 2.5% of hypertensives and completely absent in normotensives. Subjects with 4bb, G894T, and T786C genotypes showed an increased prevalence of target organ damage. Moreover prevalence of G894T and

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