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α1-adrenoceptordenervation supersensitivity in brain: Physiological and receptor binding studies

Authors
Journal
Brain Research
0006-8993
Publisher
Elsevier
Publication Date
Volume
272
Issue
1
Identifiers
DOI: 10.1016/0006-8993(83)90358-x
Keywords
  • α1-Adrenoceptor
  • Norepinephrine
  • Lateral Geniculate
  • Microiontophoresis
  • Single Unit
  • Receptor Binding
  • Denervation
  • Supersensitivity
Disciplines
  • Biology

Abstract

Abstract Electrophysiological and radioligand binding methods were used to characterize noradrenergic denervation supersensitivity atα 1-adrenoceptors in rat thalamus. Denervation was accomplished either by intraventricular or intracerebral injection of the catecholamine neurotoxin 6-hydroxydopamine (6-OHDA). In the physiological studies, the sensitivity of single lateral geniculate neurons to norepinephrine, carbachol, and serotonin was compared in sham and lesioned animals various times after 6-OHDA. Conducted in parallel were radioligand binding studies in which the density and affinity of thalamicα 1-adrenoceptors were measured with the specific antagonist [ 3H]prazosin. The results indicate that denervation produces a selective increase in the sensitivity of geniculate neurons toα 1-adrenergic stimulation and a concomitant increase inα 1-adrenoceptor density and agonist affinity.

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