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Pharmacokinetic studies of a Chinese triple herbal drug formula

Authors
Journal
Phytomedicine
0944-7113
Publisher
Elsevier
Publication Date
Volume
15
Issue
11
Identifiers
DOI: 10.1016/j.phymed.2008.01.006
Keywords
  • Formula Compatibility
  • Pharmacokinetics
  • Geniposide
  • Yin Chen Hao Tang Preparation
  • High-Performance Liquid Chromatography
Disciplines
  • Medicine
  • Pharmacology

Abstract

Abstract Yin Chen Hao Tang preparation (YCHTP) is a classic traditional Chinese medicine formula, which is commonly used for clinical treatment of hepatological diseases. In this study, a rapid and validated high-performance liquid chromatography (HPLC) method was developed to simultaneously identify 6,7-dimethylesculetin and geniposide in rat plasma. This assay was performed on a Dikma Diamonsil RP 18 column (200 mm×4.6 mm, 5 μm) with acetonitrile–methanol–water (0.1% formic acid) as the mobile phase, showing acceptable linearity, intra- and inter-day precision and accuracy (R.S.D.=5%), and absolute recovery for two analytes (74%); the limits of quantitation were 0.4 and 1.12 μg/ml, and the limits of detection were 0.06 and 0.09 μg/ml for two analytes. The developed method was successfully applied to study the effect of formula compatibility on the pharmacokinetics of 6,7-dimethylesculetin and geniposide in YCHTP when orally administrating an effective human daily dose of YCHTP to rats. We surmise that formula compatibility can significantly influence the pharmacokinetics of YCHTP, and we have elucidated and validated the compatible administration of YCHTP.

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