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Striatal cell supersensitivity to apomorphine in dopamine-lesioned rats correlated to behaviour

Authors
Journal
Neuropharmacology
0028-3908
Publisher
Elsevier
Publication Date
Volume
17
Issue
6
Identifiers
DOI: 10.1016/0028-3908(78)90005-9

Abstract

Abstract The sensitivity of glutamate-excited striatal cells to subcutaneous, systemic injections of apomorphine was measured in unlesioned rats and rats with 3–17 months old unilateral lesions of the nigro-striatal dopamine system resulting from a stereotaxic injection of 6-OH-DA into the ascending bundle of dopamine axons. The lowest doses effective in depressing striatal cell activity were used to determine the sensitivity to apomorphine: 0.1–0.4 mg/kg in unlesioned animals; 0.005 and 0.01 mg/kg in denervated animals. Thus, there is a 10–80-fold increase in striatal cell sensitivity to apomorphine after dopamine lesions. The cellular effects were comparable in sensitivity and time course to the rotational behaviour of the animals as recorded in a rotometer.

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