Affordable Access

deepdyve-link
Publisher Website

Ce6-Modified Carbon Dots for Multimodal-Imaging-Guided and Single-NIR-Laser-Triggered Photothermal/Photodynamic Synergistic Cancer Therapy by Reduced Irradiation Power.

Authors
  • Sun, Shan1, 2
  • Chen, Jingqin3
  • Jiang, Kai1
  • Tang, Zhongdi1
  • Wang, Yuhui1
  • Li, Zhongjun4
  • Liu, Chengbo3
  • Wu, Aiguo1
  • Lin, Hengwei1
  • 1 Key Laboratory of Graphene Technologies and Applications of Zhejiang Province , Ningbo Institute of Materials Technology & Engineering, Chinese Academy of Sciences , Ningbo 315201 , P. R. China. , (China)
  • 2 University of Chinese Academy of Sciences , Beijing 100049 , P. R. China. , (China)
  • 3 Institute of Biomedical and Health Engineering , Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , Shenzhen 518055 , P. R. China. , (China)
  • 4 College of Chemistry and Molecular Engineering , Zhengzhou University , Zhengzhou 45001 , P. R. China. , (China)
Type
Published Article
Journal
ACS Applied Materials & Interfaces
Publisher
American Chemical Society
Publication Date
Feb 13, 2019
Volume
11
Issue
6
Pages
5791–5803
Identifiers
DOI: 10.1021/acsami.8b19042
PMID: 30648846
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Photomediated cancer therapy, mainly including photothermal (PT) therapy (PTT) and photodynamic therapy (PDT), has attracted tremendous attention in recent years thanks to its noninvasive and stimuli-responsive features. The single mode of PTT or PDT, however, has obvious drawbacks, either requiring high-power laser irradiation to generate enough heat or only providing limited efficacy due to the hypoxia nature inside tumors. In addition, the reported synergistic PTT/PDT generally utilized two excitation sources to separately activate PTT and PDT, and the problem of high-power laser irradiation for PTT was still not well solved. Herein, a new concept, loading a small amount of photosensitizers onto a PTT agent (both of them can be triggered by a single-near-infrared (NIR) laser), was proposed to evade the shortcomings of PTT and PDT. To validate this idea, minute quantities of photosensitizer chlorin e6 (Ce6) (0.56% of mass) were anchored onto amino-rich red emissive carbon dots (RCDs) that possess superior photothermal (PT) character under 671 nm NIR laser (PT conversion efficiency to be 46%), and meanwhile the PDT of Ce6 can be activated by this laser irradiation as well. The findings demonstrate that Ce6-modified RCDs (named Ce6-RCDs) offer much higher cancer therapy efficacy under a reduced laser power density (i.e., 0.50 W cm-2 at 671 nm) in vitro and in vivo than the equivalent RCDs or Ce6 under the same irradiation conditions. Besides, the Ce6-RCDs also exhibit multimodal imaging capabilities (i.e., fluorescence (FL), photoacoustic (PA), and PT), which can be employed for guidance of the phototherapy process. This study suggests not only a strategy to enhance cancer phototherapy efficacy but also a promising candidate (i.e., Ce6-RCDs) for multimodal FL/PA/PT imaging-guided and single-NIR-laser-triggered synergistic PTT/PDT for cancers by a reduced irradiation power.

Report this publication

Statistics

Seen <100 times