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Effects of haloperidol on afternoon sleep and on the secretion of growth hormone in man

Authors
Journal
Neuroscience
0306-4522
Publisher
Elsevier
Publication Date
Volume
3
Issue
3
Identifiers
DOI: 10.1016/0306-4522(78)90083-0
Disciplines
  • Medicine

Abstract

Abstract The sleep pattern and the plasma concentration of growth hormone were determined during afternoon naps of seven healthy young subjects after i.v. treatment with 3.5 mg haloperidol. The latency of sleep onset and the period in stage 2 were reduced, but the time spent awake was increased compared to control conditions. The magnitude of the sleep induced peak in growth hormone concentration was not modified in five subjects. In two subjects it was abolished as a consequence of shortened sleeping time and disturbed sleep. It is suggested that unlike growth hormone secretion induced by endocrine or metabolic factors, that occurring during sleep is not mediated by a central dopaminergic neuronal pathway.

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